Ozone was used in the First World War for its antibacterial and anti-inflammatory properties

Noble actions and a wide range of properties are the impetus for exploring and developing the field in which ozone can act and help each person.

Even during the First World War (1914-1918) doctors familiar with the antibacterial properties of ozone and used it on infected wounds, also found that O3 not only removed the infection but also had hemodynamic and anti-inflammatory properties. Its use increased in order to save a greater number of soldiers and reduce the rate of amputations. With the use by military doctors until 1920, ozone was widely spread in Europe and parts of the United States. In the 1930s, Swiss dentist Dr. Fish used ozone in his ordination and published many works for its use in dental science.

In 1940, a German doctor named Hans Wolff wrote a book called "Medical Ozone" which is still used today. During World War II, a doctor named Robert Meyer learned how ozone was used for the German military forces and included it in his practice for decades.